During non urgent surgery, general anesthesia might induce enterocyte damage. I-FABP is a performant biomarker of enterocyte damage. We aimed to study whether patient ongoing general anesthesia for non-urgent surgery have an elevation of plasma I-FABP concentration.
Inclusion criteria * Indication of non-urgent surgery * General anesthesia protocol using propofol and remifentanyl * One half of the patients have a history of ischemic arteriopathy * One half of the patients have no history of ischemic arteriopathy Exclusion criteria * Age \< 18 years old * Pregnant Primary objective Is there a significant elevation of I-FABP between the pre-anesthesic period and 11 minutes after induction of general anesthesia ? Secondary objectives 1. Is I-FABP elevation higher among patients with history of patent arteriopathy ? 2. Is I-FABP elevation higher among patients presenting with hypotension during anesthesia ?
Study Type
OBSERVATIONAL
Enrollment
50
CHRU de Besançon
Besançon, France
RECRUITINGI-FABP elevation after induction of general anesthesia
Primary measure of plasma I-FABP before induction of general anesthesia. Second measure of plasma I-FABP concentration 11 minutes after induction of general anesthesia using a protocol of propofol and remifentanyl with monitoring of bispectral index.
Time frame: 11 minutes
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