Anesthesia and Motor Evoked Potential (MEP) Recruitment

N/ACompletedNCT02199314

Children's Hospital Medical Center, Cincinnati30 enrolled

Overview

Test the hypothesis to recruit larger motor responses to transcranial stimulation.

The study is designed to test the hypothesis that it is possible to recruit larger motor responses to transcranial stimulation by increasing the number of stimulating pulses under both baseline conditions and conditions of increased anesthetic suppression of the motor responses.

Study Type

INTERVENTIONAL

Allocation

Purpose

PREVENTION

Masking

NONE

Enrollment

Conditions

Idiopathic Scoliosis

Interventions

DesfluraneDRUG

Eligibility

Sex: ALLMin age: 12 YearsMax age: 17 Years

Medical Language ↔ Plain English

Inclusion Criteria: * Age 12 through 17 years * Diagnosis of idiopathic scoliosis * Scheduled for posterior spinal fusion with neurophysiological monitoring * No known allergies to propofol or remifentanil * No contraindication to total intravenous anesthesia * No contraindications to the administration of volatile agents Exclusion Criteria: * Failure to consent or assent to study * Diagnosis other than idiopathic scoliosis * Poorly controlled seizures or the presence of a cochlear implant * Patient history or family history of malignant hypothermia or mitochondrial myopathies

Locations (1)

Cincinnati Children's Hospital Medical Center

Cincinnati, Ohio, United States

Outcomes

Primary Outcomes

Effect of Pulse Train Length on Transcranial Motor Evoked Potentials (TcMEP) Area Under Total Intravenous Anesthesia (TIVA) and TIVA Plus 3% Desflurane

A series of 15 transcranial motor evoked potentials are recorded under a TIVA anesthetic and again after addition of 3% desflurane for 5 minutes at two different time points in a surgical procedure. The series consisted of 3 runs of 5,6, 7, 8, and 9 pulse trains, each train separated by 30 seconds. The 3 runs were averaged to give and average value of TcMEP amplitude and area for the 5,6,7,8 and 9 pulse trains. The data were used to compute regression coefficients for area vs pulse length for the TIVA case and TIVA plus desflurane for each participant who completed the study..The final measure is the number of participants who had a MEP area ratios significantly different from 1 at all times and conditions; that is for TIVA alone and TIVA plus desflurane, at both time points.

Time frame: 15 minutes

Data from ClinicalTrials.gov

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