As we know propofol is popular use in the anesthesia induction with kilogram and it always cause hypotension. So we compare haemodynamic changes and drug consumption between propofol titrated administration and traditional administration for anesthesia induction.
GroupⅠreceived propofol 2 mg/kg intravenously by Fresenius pump at the speed of 250 mg/min, GroupⅡreceived propofol intravenously by Fresenius pump at the speed of 1 mg/kg/min, and observe's assessment of alertness and sedation(OAA/S) scale of the patients was titrated to 1, then changed to a maintenance dose
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
TREATMENT
Masking
DOUBLE
Enrollment
160
propofol intravenously by Fresenius pump at the speed of 1 mg•kg-1•min-1, and OAA/S scale of the patients was titrated to 1
Department of Anesthesia ,Sixth Affiliated hospital of Sun Yat-sen University
Guangzhou, Guangdong, China
systolic pressure diastolic pressure mean blood pressure
before propofol dosage ,1 min after the propofol dosage, 3 min , 5 min , endotracheal intubation done immediately,1 min,3 min,5 min,7 min,9 min after endotracheal intubation
Time frame: 15minutes
total dosage of propofol using
Time frame: 15 minutes
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