Cachexia associated with cancer is a grave and most of the time irreversible common situation. It seems independent from the size of the tumor or from its metastatic character. The consequences for the management of the patient are major and exceed widely the frame of the nutrition. Undernutrition of patients with cancer is described by a decrease of the energy contributions and a loss of muscular and fat mass, leading to a progressive functional deficiency which can go to the cachectic state. Actually, clinical criteria are proposed allowing to characterize the state of pre-cachexia but it remain too indistinct to allow an early and efficient screening and set up effective measures of prevention of the cachexia, to avoid the loss of muscular tissue and the cast iron of the energy reserves. It is necessary to have clinical and biological markers with diagnostic aim and forecasts during the situations precedents the appearance of cachexia. The present study will allow calibrating a longitudinal study, which could confirm the value of measures made for the diagnosis of pre-cachexia.
Study Type
INTERVENTIONAL
Allocation
NA
Purpose
OTHER
Masking
NONE
Enrollment
59
Evaluation of physical composition (non-invasive method)
Nutritional status will be assessed by using the "Mini Nutritional Assessment" (MNA) questionnaire and a scale that evaluates anorexia
This will be assessed by using a "tiredness scale" named "Echelle Visuelle Analogique" (EVA) in french
Muscular strength will be assessed thanks to the Handgrip Strength Test and the Short Physical Performance Battery (SPPB)
The emotional status wil be assessed thanks to the Yesavage Geriatric Depression Scale (GDS)
The functional status will be assessed by using the Activity of Daily Life (ADL) questionnaire and the Instrumental Activities of Daily Living (IADL) Questionnaire
Groupement Hospitalier Sud - Service de Médecine Gériatrique
Pierre-Bénite, France
biological and radiological markers
Validated criteria of cachexia, pre-cachexia and sarcopenia are applied. Systematic preoperative measures (TNFα, leptin, ghrelin) and CT scanning of the abdomen/pelvis are performed for all patient enrolled.
Time frame: During perioperative period (from date of consent until discharge from the hospital, up to 30 postoperative days)
activity of the ATGL
The activity of ATGL is determined by liquid scintillation counting.
Time frame: During perioperative period (From date of consent until discharge from the hospital, up to 30 postoperative days)
Body composition
Body composition is evaluated utilizing computerized tomography(CT) images (at the third lumbar vertebral level). A muscle index is also calculated by normalizing muscle areas for height.
Time frame: During perioperative period (from date of consent until discharge from the hospital, up to 30 postoperative days)
metabolic phenotype
metabolic phenotype is determinated by indirect calorimetry.
Time frame: During perioperative period (From date of consent until discharge from the hospital, up to 30 postoperative days)
loss of fat body mass and/or lean body mass
Lean body mass and components (intracellular water and extracellular water as well as body cell mass) were calculated by tetrapolar bioelectrical impedance analysis
Time frame: During perioperative period (From date of consent until discharge from the hospital, up to 30 postoperative days)
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