The Effects of Cyclosporin A in a Low Humidity Environment, on the Ocular Surface

Inclusion Criteria: * Signature on the written informed consent form * Patient willingness and ability to return for all visits during the study * Rapid tear film break up time of seven seconds or less in at least one eye AND * Both cornea fluorescein staining score greater than or equal to 3 and conjunctival lissamine green staining greater than or equal to 3 in at least one eye * Ocular Surface Disease Index Symptom Severity score of twenty or greater * Tear meniscus height less than or equal to 230um * Intact corneal sensitivity * Willingness to discontinue use of any current dry eye treatment (except artificial tears) for four weeks prior to enrollment, and during the course of the study Exclusion Criteria: * Compromised cognitive ability which may be expected to interfere with study compliance * Uncontrolled or poorly controlled diabetes or heart or pulmonary disease that could, in the judgment of the investigator, jeopardize subject safety or interfere with the interpretation of the results of the study * Known hypersensitivity to any components of the artificial tears or cyclosporin A eye drops Anticipated contact lens wear during the study * History of corneal transplant * Active ocular infection, uveitis or non-KCS related inflammation * History of cataract surgery within 3 months prior to enrollment * History of pterygium removal within 6 months prior to enrollment * Reduced corneal sensitivity * Initiation, discontinuation or change in dosage of hormone replacement therapy (HRT), fish oil, evening primrose, flaxseed, or black current seed oil supplements, antihistamines, cholinergic agents, beta-blocking agents, tricyclic or SSRI antidepressants, phenothiazines, or topical or systemic acne rosacea medications in two months prior to enrollment, or anticipated change in dosage during course of study * Topical ophthalmic medications within prior 4 weeks, or anticipated use of same during the study (except artificial tears) * Occlusion of the lacrimal puncta either surgically or with temporary collagen punctal plugs within three months prior to study, or anticipated use of same during study