MR-guided Focal Laser Ablation of the Prostate

Inclusion Criteria: * Newly diagnosed and biopsy proven prostate cancer * Intermediate risk patients (PSA \<= 20 ng/mL, Gleason ≤ 7, T2b) * No previous treatment for prostate cancer * Cancer lesion located at least 1 cm away from the neurovascular bundle according to Multimodality MR images * Signed informed consent by patient * Age 18 years or older * Signed screening form (to determine exclusion for metal device/foreign bodies/claustrophobia) Exclusion Criteria: * Impossibility to obtain a valid informed consent * Patients unable to undergo MR imaging, including those with contra-indications * Contra-indications to MR guided focal laser therapy (colitis ulcerosa, rectal pathology or abdomino perineal resection) * Metallic hip implant or any other metallic implant or device that distorts local magnetic field and compromises the quality of MR imaging * Patients with evidence for nodal or metastatic disease * Patients with an estimated Glomerular Filtration Ratio (eGFR) \< 40 mL/min/1.73 m2