Luteal Phase Supplementation With Recombinant LH After GnRh Agonist Oocytes Triggering in Women at Risk of OHSS

N/ACompletedNCT02200952

San Carlo Public Hospital, Potenza, Italy16 enrolled

Overview

The purpose of this study is to prove that luteal phase supplementation with recombinant LH can solve the luteal phase deficiency after Gnrh agonist oocytes triggering in women at risk of OHSS

The investigators enrolled patients, undergoing controlled ovarian stimulation for an IVF/ICSI cycles, who on the day of oocytes triggering were at risk of OHSS. These patients had an estradiol \> 4000 pg/ml and more than 24 follicles with a diameter greater than 12 mm. The investigators used 0,2 mg of triptorelin for the oocytes triggering and supplemented the luteal phase with recombinant LH at a dose of 75 UI twice/day for 10 days and vaginal gel progesterone and oral oestradiol for 14 days The investigators measured bhCG at 14 days from the pick up. In case of positive bhCG we have defined the IVF/ICSI outcome: Pregnancy Rate and Implantation Rate.

Study Type

OBSERVATIONAL

Enrollment

Conditions

Ovarian Hyperstimulation Syndrome

Interventions

recombinant LHDRUG

recombinant LH twice/day for 10 days from pick up

Eligibility

Sex: FEMALEMin age: 18 YearsMax age: 43 Years

Medical Language ↔ Plain English

Inclusion Criteria: * patients with an oestradiol \> 4000 pg/ml on the oocytes triggering day * patient with more than 24 follicles of diameter greater than 12 mm on the oocytes triggering day Exclusion Criteria: * patients with no risk of OHSS on the oocytes triggering day * patients with an oestradiol \< 4000 pg/ml on the oocytes triggering day * patient with less than 24 follicles of diameter greater than 12 mm on the oocytes triggering day

Locations (1)

San carlo Public Hospital

Potenza, Basilicate, Italy

Outcomes

Primary Outcomes

Pregnancy Rate and Implantation Rate

We measured bhCG after 14 days from the pick up. In presence of a positive value of bhCG we evaluated IVF/ICSI outcome through the pregnancy rate and implantation rate.

Time frame: From 14 days after the pick up to six weeks of gestation

Secondary Outcomes

Ealy and Late Ovarian Hyperstimulation Syndrome

We evaluated early and late ovarian hyperstimulation syndrome according the practice committee of ASRM 2008 and Current Clinical Guideline for OHSS of 2010

Time frame: From 9 days after pick up to 12 weeks of gestation

Data from ClinicalTrials.gov

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