Influences of Phenylephrine, Dopamine and Ephedrine on Stroke Volume Variation and Pulse Pressure Variation

N/ACompletedNCT02201121

Chinese PLA General Hospital94 enrolled

Overview

Although induced hypertension decreased SVV and PPV,the influences of stroke volume variation and pulse pressure variation caused by phenylephrine,dopamine and ephedrine were unknown.

Pulse pressure variation (PPV) and stroke volume variation (SVV) during mechanical ventilation have been shown to be effective parameters to predict preload responsiveness. Although induced hypertension decreases PPV and SVV, the influences of phenylephrine, dopamine and ephedrine on PPV and SVV are unknown.

Study Type

INTERVENTIONAL

Allocation

Masking

SINGLE

Enrollment

Conditions

Circulation Drug Dose Calculated SAP

Interventions

Influences of phenylephrine, dopamine and ephedrine on stroke volume variation and pulse pressure variationOTHER

This research mainly study the effect of clinical commonly used vasoconstrictor drugs on blood pressure of pressure

Eligibility

Sex: ALLMin age: 18 YearsMax age: 60 Years

Medical Language ↔ Plain English

Inclusion Criteria: * Their American Society of Anesthesiologists (ASA) physical status was 1 or 2 * Body mass index (BMI) ranged from 18 to 26 * None of the patients had known diabetes mellitus, hypertension, cardiovascular, pulmonary, endocrinological, neurological diseases, or diseases that influenced intravascular fluid volume or balance * All patients had a preoperative fast for at least 8 h and routine atropine intramuscular injection Exclusion Criteria: * Persistent arrhythmias * Intraoperative application of vasoactive drugs except phenylephrine, dopamine and ephedrine

Outcomes

Primary Outcomes

invasive arterial blood pressure as a Measure of Safety

if instability of circulation, stop the clinical trial

Time frame: DAY 1

Data from ClinicalTrials.gov

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