Bortezomib in Rejection of Kidney Transplants

Inclusion Criteria: * recipients of a first or a second kidney transplant for more than 3 months * age over 18 years * with de novo donor specific antibodies (DSA), i.e. antibodies not detected the day of transplantation and in pre-transplant sera * with histological lesions of chronic active antibody-mediated rejection (glomerulitis + peritubular capillaritis banff score and chronic glomerulopathy (g+ptc ≥ 2) on a graft biopsy performed because of renal function deterioration, proteinuria, detection of de novo DSA, or on a systematic biopsy * written informed consent * Given the teratogenic risks described in the SPCs of Velcade and Cellcept: * Women of child bearing age must have a negative pregnancy test the day of the inclusion and should use at least one effective contraceptive method before start of medication during the treatment and during the study * Men old enough to procreate have to use condoms during the treatment and at least 90 days after the last intake of the treatment during the study. Moreover, given SPCs of Cellcept, it is recommended that female partners to use an effective method of contraception treatment and for 90 days after the last mycophenolate intake by the partner male * affiliated with social security health insurance * patients with cell rejection lesions associated with chronic humoral rejection lesions active may be included in the study. This rejection can be treated with 3 boluses of 500 mg of methyl prednisolone prior to inclusion. Exclusion Criteria: * patient with preformed DSA * recipient of a 3rd or 4th kidney transplant * recipient of a transplant combined with another not renal organ * patient with a history of humoral acute rejection during the current transplantation * estimated GFR below 20 ml/min/1,73m2 * severe transplant glomerulopathy (cg score = 3) * severe peripheral neuropathy, thrombopenia \< 100 000 mm3 , neutropenia \< 1000 mm3 and/or an uncontrolled evolutionary infection * chronic active hepatitis B (positive HBs antigen or HBV DNA), positive chronic hepatitis C and/or known HIV infection * allergy to bore or bortezomib or to one of the excipient * hepatic failure, abnormal liver tests (bilirubin \>3N, transaminases \>3n), infiltrative pneumopathy, pericarditis * risk of non-adherence to treatment or protocol * inclusion in another clinical therapeutic trial