Effect of Induction and Maintenance of Anesthesia With Etomidate on Hemodynamics and Oxidative Stress in Diabetic Patients

Phase 4UnknownNCT02202239

Zhujiang Hospital60 enrolled

Overview

To explore the effect of induction and maintenance of anesthesia with etomidate on hemodynamics and oxidative stress in diabetic patients.

Study Type

INTERVENTIONAL

Allocation

RANDOMIZED

Purpose

TREATMENT

Masking

DOUBLE

Enrollment

Conditions

Hemodynamics Oxidative Stress Anesthesia

Interventions

midazolamDRUG

Before induction, midazolam 0.05mg/kg will be injected intravenously.

Penehyclidine Hydrochloride InjectionDRUG

Penehyclidine Hydrochloride 0.01mg/kg will be injected intravenously after midazolam is injected.

EtomidateDRUG

Induction dose: 0.3 mg/kg. Maintenance dose: 10 μg•kg-1•min-1.

Eligibility

Sex: ALLMin age: 18 YearsMax age: 65 Years

Medical Language ↔ Plain English

Inclusion Criteria: * Aged between 18 and 65 years; * Diabetic patients preparing for elective surgery; * Body mass index is between 16 and 30 kg/m2; * Blood glucose is under 8.3 mmol/kg by oral antidiabetic agents or diet control; * American Society of Anesthesiology (ASA) Physical Status: Ⅰ or Ⅱ; * Expected operation duration is between 2 and 8 h; * Signed informed consent form. Exclusion Criteria: * Severe cardiac, cerebral, liver, kidney, lung, endocrine disease or infectious disease; * Chemotherapy or immunotherapy before the surgery; * Allergy to trial drug or other contraindication; * Expected or history of difficult airway; * Suspected abuse of narcotic analgesia; * Diseases of neuromuscular system; * Mentally unstable or has a mental illness; * Trend of malignant hyperthermia; * Pregnant or breast-feeding women; * Attendance of other trial past 30 days.

Outcomes

Primary Outcomes

Mean arterial pressure

Mean arterial pressure will be measured 10 min before the induction (T0), at intubation (T1), 5 min (T2), 15 min (T3) after intubation, 30 min after the beginning of the surgery (T4) and 1 h after the end of the surgery. Beginning of the surgery: beginning of skin incision. End of the surgery: skin suture is finished.

Time frame: from 10 minutes before induction to 1 h after the surgery

Central venous pressure

Central venous pressure will be measured 10 min before the induction (T0), at intubation (T1), 5 min (T2), 15 min (T3) after intubation, 30 min after the beginning of the surgery (T4) and 1 h after the end of the surgery. Beginning of the surgery: beginning of skin incision. End of the surgery: skin suture is finished.

Time frame: from 10 minutes before induction to 1 h after the surgery

Heart rate

Heart rate will be recorded 10 min before the induction (T0), at intubation (T1), 5 min (T2), 15 min (T3) after intubation, 30 min after the beginning of the surgery (T4) and 1 h after the end of the surgery. Beginning of the surgery: beginning of skin incision. End of the surgery: skin suture is finished.

Time frame: from 10 minutes before induction to 1 h after the surgery

Respiratory rate

Respiratory rate will be measured 10 min before the induction (T0), at intubation (T1), 5 min (T2), 15 min (T3) after intubation, 30 min after the beginning of the surgery (T4) and 1 h after the end of the surgery. Beginning of the surgery: beginning of skin incision. End of the surgery: skin suture is finished.

Time frame: from 10 minutes before induction to 1 h after the surgery

Oxygen saturation

Oxygen saturation will be measured 10 min before the induction (T0), at intubation (T1), 5 min (T2), 15 min (T3) after intubation, 30 min after the beginning of the surgery (T4) and 1 h after the end of the surgery. Beginning of the surgery: beginning of skin incision. End of the surgery: skin suture is finished.

Data from ClinicalTrials.gov

This platform is for informational purposes only and does not constitute medical advice. Always consult a qualified healthcare professional.

Secondary Outcomes

Super oxide dismutase

2 ml blood will be collected 10 min before the induction (T0), at intubation (T1), 5 min (T2), 15 min (T3) after intubation, 30 min after the beginning of the surgery (T4) and 1 h after the end of the surgery. The blood will be preserved below -20 ℃ before super oxide dismutase was measured. Beginning of the surgery: beginning of skin incision. End of the surgery: skin suture is finished.

Time frame: from 10 minutes before induction to 1 h after the surgery

Glutathione

2 ml blood will be collected 10 min before the induction (T0), at intubation (T1), 5 min (T2), 15 min (T3) after intubation, 30 min after the beginning of the surgery (T4) and 1 h after the end of the surgery. The blood will be preserved below -20 ℃ before glutathione was measured. Beginning of the surgery: beginning of skin incision. End of the surgery: skin suture is finished.

Time frame: from 10 minutes before induction to 1 h after the surgery

Xanthine oxidase

2 ml blood will be collected 10 min before the induction (T0), at intubation (T1), 5 min (T2), 15 min (T3) after intubation, 30 min after the beginning of the surgery (T4) and 1 h after the end of the surgery. The blood will be preserved below -20 ℃ before xanthine oxidase dismutase was measured. Beginning of the surgery: beginning of skin incision. End of the surgery: skin suture is finished.

Time frame: from 10 minutes before induction to 1 h after the surgery