Acute, randomized, placebo controlled, double blind, 4 arm crossover study to determine the effect of different combinations of plant based extracts on cognitive function and cerebral blood flow.
The objectives of this study are to assess the effects of oral consumption of three differing combinations of plant based extracts, on cognitive function and cerebral blood flow (using Near infrared Spectroscopy) in comparison to placebo. The primary outcome will be change in cognitive function and mental fatigue during extended performance of the Cognitive Demand Battery (CDB) at 1, 3 and 6 hours post- consumption.
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
BASIC_SCIENCE
Masking
DOUBLE
Enrollment
32
Intervention involves single exposure, oral consumption of test article following baseline measurements
Northumbria University
Newcastle upon Tyne, United Kingdom
Change in cognitive function and fatigue during extended performance of the Cognitive Demand Battery (CDB) at 1, 3 and 6 hours post consumption Change in long term declarative memory at 1, 3 and 6 hours post-intervention.
Time frame: 1-6 hours post intervention
Change in executive function at 1, 3 and 6 hours post intervention.
Time frame: 1-6 hours post intervention
Change in cerebral blood flow parameters (oxygenated and deoxygenated haemoglobin levels and their sum) in the frontal cortex during task performance commencing at 1, 3 and 6 hours post-intervention.
Time frame: 1-6 hours post intervention
Change in episodic memory, as measured by immediate word recall, at 1, 3 and 6 hours post intervention.
Time frame: 1-6 hours post intervention
Change in mood ratings, at 1,3 and 6 hours post intervention.
Time frame: 1-6 hours post intervention
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