Evaluation of Richmond Agitation Sedation Scale According to Alveolar Concentration of Sevoflurane During a Sedation With Sevoflurane in ICU Patients

Phase 2CompletedNCT02202720

University Hospital, Clermont-Ferrand30 enrolled

Overview

Describe the Richmond Agitation Sedation Scale (RASS) values corresponding to the values of Minimum alveolar concentration of sevoflurane during sedation of patients in ICU

Prospective clinical study in ICU with sedated ventilated patients with sevoflurane using the Mirus® system. Pharmacological study of the concentration-effect relationship by administration at increasing and decreasing concentrations.

Study Type

INTERVENTIONAL

Allocation

Purpose

TREATMENT

Masking

NONE

Enrollment

Conditions

Requiring Sedation by Sevoflurane in ICU Adult Patients Patients Covered by French Health Care System Patients Who Have Given Their Consent

Interventions

SevofluraneDRUG

Short term sedation with sevoflurane in ICU

Eligibility

Sex: ALLMin age: 18 Years

Medical Language ↔ Plain English

Inclusion Criteria: * Requiring sedation by sevoflurane in ICU * Adult patients * Patients covered by french health care system * Patients who have given their consent or his family Exclusion Criteria: * Pregnant or lactating women * Sevoflurane anaphylaxia * Known or suspected risk of malignant hyperthermia * Refusal Protocol * Brain-damaged patients * Hemodynamic conditions not compatible with the use of sevoflurane * ARDS patients * Minor patients

Locations (1)

CHU Clermont-Ferrand

Clermont-Ferrand, France

Outcomes

Primary Outcomes

Description of the RASS score

Describe the RASS score corresponding to the values of sevoflurane MAC during sedation of patients in ICU : RASS score determined at the middle of each level of 30 minutes, each level correspond to determined sevoflurane MAC with ascending MAC ranging from 0 to 0.8 and then descending MAC from 0.8 to 0.

Time frame: at day 1

Secondary Outcomes

determination of the associated hemodynamic and respiratory parameters

Determine the associated hemodynamic and respiratory parameters, bispectral index and analgesia-nociception index for each level of sevoflurane MAC (monitored at the middle of each level of 30 minutes).

Time frame: at day 1

Data from ClinicalTrials.gov

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