Electric Acupuncture for ICU-acquired Weakness in Mechanical Ventilation Patients

N/AUnknownNCT02204215

Jiangsu Province Hospital of Traditional Chinese Medicine40 enrolled

Overview

Intensive care unit acquired weakness (ICU-AW) is common and dramatically affect recovery. The purpose of this study is to determine whether electric acupuncture therapy is effective in the treatment of ICU-AW especially in the patients receiving mechanical ventilation with sepsis or multiorgan system failure.

The principle of acupuncture is to produce bioelectric current, as a consequence, to invigorate the circulation, promote tissue regeneration, relieve pain, enhance the immune function, etc. And electric acupuncture can stimulate bioelectricity activities at acupoints, out of reach for ordinary acupuncture effect, especially in the fields of nerve/muscle recovery and regeneration.

Study Type

INTERVENTIONAL

Allocation

Purpose

TREATMENT

Masking

NONE

Enrollment

Conditions

Respiratory Failure Sepsis Multiple Organ Dysfunction Syndrome

Interventions

electric acupunctureDEVICE

Electric acupuncture therapy was made on LI4, LI11, ST36, and ST41 on four limbs for each patient, 30 min for each time, twice per day. Starting from the beginning of mechanical ventilation, to the weaning of the mechanical ventilation.

conservativeOTHER

General treatment, without electric acupuncture, include passive range-of-motion exercise，q2H turning，minimizing the use of sedation, etc.

Eligibility

Sex: ALLMin age: 18 YearsMax age: 80 Years

Medical Language ↔ Plain English

Inclusion Criteria: * Clinical diagnosis of sepsis or multiple organ dysfunction syndrome * Within 48 hours from the initiation of mechanical ventilation Exclusion Criteria: * Pregnant patients * Neuromuscular disease or cerebrovascular accident * With temporary or permanent pacemaker * Need to use neuromuscular blocking agents * Inactivity for more than 5 days before ICU admission

Locations (1)

Department of Intensive Care Unit, Jiangsu Province Hospital of TCM

Nanjing, Jiangsu, China

Outcomes

Primary Outcomes

strength related parameters

muscle force, arm circumference, skin fold thickness

Time frame: Participants will be followed until the date of weaning from mechanical ventilation, an expected average of 8 weeks

Secondary Outcomes

mechanical ventilation duration

the time span from the beginning of mechanical ventilation, till the weaning of mechanical ventilation

Time frame: Participants will be followed until the date of weaning from mechanical ventilation, an expected average of 8 weeks

28-day mortality

the mortality till the 28th day after mechanical ventilation

Time frame: Participants will be followed until the 28th day after mechanical ventilation

number of participants with adverse events of electric acupuncture

the adverse enents include fainting, infection, bleeding, viscera damage, and so on.

Time frame: Participants will be followed until the date of weaning from mechanical ventilation, an expected average of 8 weeks

ICU duration

the time span from the beginning of mechanical ventilation, till the date of discharge from the ICU

Time frame: Participants will be followed until the date of discharge from the ICU, an expected average of 8 weeks

Data from ClinicalTrials.gov

This platform is for informational purposes only and does not constitute medical advice. Always consult a qualified healthcare professional.