Clinical Study for the Evaluation of the Depigmenting Activity of a Cosmetic Product on Spotted Hand Skin

Inclusion Criteria: * female healthy subjects * age 45-65 years * presence of moderate senile lentigo on the back of the hands * accepting to not receive any drugs/cosmetic/chemical or physical treatment (peeling, intradermal implants etc.) able to change the skin characteristics during the entire duration of the study * accepting to use the study product according to the instruction received by the investigator * accepting not to expose to strong UV irradiation (UV session, or sun bathes) during the entire duration of the study * subject agreeing not to use anti-spots products/treatments during the month preceding the test * accepting to sign the Informed Consent Form Exclusion Criteria: * pregnancy * lactation * sensitivity to the test product or its ingredients * subjects whose insufficient adhesion to the study protocol is foreseeable * participation in a similar study actually or during the previous 3 months * dermatological disease (dermatitis; presence of cutaneous disease on the tested area, as lesions, scars, malformations) * clinical and significant skin condition on the test area (e.g. active eczema, dermatitis, psoriasis. etc.) * diabetes * endocrine disease * hepatic disorder * renal disorder * cardiac disorder * pulmonary disease * cancer * neurological or psychological disease * inflammatory/immunosuppressive disease * drug allergy * systemic corticosteroids * aspirin or non-steroid anti-inflammatory drugs (FANS) * anti-histaminic, narcotic, antidepressant, immunosuppressive drugs (with except of contraceptive or hormonal treatment starting from at least 1 year) * assumption of drugs able to influence the test results in the investigator opinion