A Drug-Drug Interaction Study to Evaluate the Effect of Vapendavir on the Pharmacokinetics of Midazolam in Healthy Male and Female Volunteers

Inclusion Criteria: * Must be male or female between 18 and 55 years of age (inclusive) with BMI between 18 and 30 kg/m2 (inclusive), and weight ≥50 kg at the time of screening; * Capable of giving written informed consent; * Subject is able to understand and comply with the protocol requirements, instructions and restrictions; * Healthy on the basis of physical examination, medical history, medication usage, vital signs (VS), electrocardiograms (ECGs), and clinical laboratory tests; * Female subjects who are not post-menopausal for at least 2 years or surgically sterile with complete hysterectomy or bilateral oophorectomy and male subjects who are not surgically sterile via vasectomy, must agree to use a double barrier method of birth control, such as a condom plus spermicidal agent (foam/gel/film/cream/suppository); and * Female subjects must not be breastfeeding or pregnant. Exclusion Criteria: * Positive results for Hepatitis B, Hepatitis C, or HIV; * Frequent use (defined as \> 5 times/day) of tobacco products, including cigarettes, cigars, chewing tobacco; * A medical history of significant hematological, gastrointestinal, respiratory, renal, hepatic, cerebrovascular, immunologic, psychiatric or cardiovascular disease or event; * Current or recent respiratory infection (defined as within 14 days of first study visit participation) * Presence or history of significant allergy; * Clinically significant abnormalities noted on ECG; * Screening vital signs representing sustained elevated systolic blood pressure \<90 mmHg or \>140 mmHg, and/or diastolic blood pressure \<55 mmHg or \>90 mmHg. * Presence of significant gastrointestinal abnormalities such as diarrhea or constipation; * Safety laboratory abnormalities noted at screening which are clinically significant * Current or defined history of abuse of alcohol or illicit drugs; * A positive pregnancy test at screening; * Poor vein access or fear of venipuncture or sight of blood; and * Regular consumption of alcohol defined as either \> 2 units (glass or shot) of alcoholic beverages per day or \> 14 units per week.