Role of Parecoxib Sodium for Postoperative Pain Management in Open Hepatectomy

Inclusion Criteria: * Age between 20-70 years old; * Hepatic hemangioma patients who will undergo laparotomy surgery: diameter of hepatic hemangioma between 5-15cm, located in the right liver; * Child score 5-6; * BMI: 19-25; * ASA: Ⅰ \~ Ⅱ grade; * No comorbidities such as diabetes, hypertension, cardio renal or respiratory dysfunction, mental illness; * No known allergies; * No participation in other clinical trials within 2 months; * Have been informed consent. * Surgery-related: right subcostal incision, surgical time\< 4 hours, hepatic pedicle occlusion time\< 20 minutes, bleeding\< 1000ml, no blood transfusions. Exclusion Criteria: * History of chronic pain，long-term use of analgesic drugs or alcohol abuse; * Allergic to NSAIDs, opioids or sulfa drugs; * Coagulopathy or other hematological disorder； * Active peptic ulcer, gastrointestinal bleeding, inflammatory bowel disease; * Pregnant or lactating; * Mentally unstable to use PCA; * Preoperative pain caused by other disease; * Analgesic drugs or NSAIDs intake one week before surgery; * Preoperative systemic inflammatory response syndrome; * Preoperative chemotherapy or radiotherapy; * Preoperative or postoperative use of steroids; * Operative time\> 4 hours, hepatic pedicle occlusion time\> 20 minutes, blood loss\> 1000ml, or intraoperative blood transfusion; * TBil\> 34 umol/L、PT prolongation\> 3S、ALB\< 30 g/L、or Child score\> 7 within 42 hours after surgery； * Bleeding、biliary fistula, intra-abdominal infections or other postoperative complications.