Urinary Leukotriene E4 Levels in Children With Obstructive Sleep Apnea

N/ACompletedNCT02205346

Eastern Virginia Medical School130 enrolled

Overview

Investigate urinary leukotriene E4 levels and determine if there is a correlation with severity of obstructive sleep apnea. The investigators then would like to determine a threshold level which could then be used for confirmation of diagnosis of obstructive sleep apnea (OSA).

Study Type

OBSERVATIONAL

Enrollment

130

Conditions

Obstructive Sleep Apnea

Eligibility

Sex: ALLMin age: 2 YearsMax age: 16 Years

Medical Language ↔ Plain English

Inclusion Criteria: * children 2-16 years of age * scheduled for polysomnogram Exclusion Criteria: * cardiovascular, neuromuscular, immunologic or craniofacial disorders * pharmacologic treatment including corticosteroids and leukotriene receptor antagonists in the last month * subjects who have already received treatment for OSA with an oral appliance, continuous positive airway pressure (CPAP) device * previously undergone tonsillectomy and/or adenoidectomy

Locations (1)

Children's Hospital of the King's Daughters

Norfolk, Virginia, United States

Outcomes

Primary Outcomes

urine leukotriene level

assess urinary leukotriene E4 levels in children with obstructive sleep apnea (OSA

Time frame: baseline

Secondary Outcomes

correlation between Urine LTE4 and the apnea hypopnea index (AHI)

determine if there is a correlation between urine LTE4 levels and the severity score as determined by the AHI

Time frame: baseline

Data from ClinicalTrials.gov

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