Continuous Intravenous Sufentanil Infusion for Postoperative Pain Management Following Tonsillectomy or Adeno-tonsillectomy in Children

Phase 4UnknownNCT02205580

Jin Ni60 enrolled

Overview

Postoperative pain following tonsillectomy or adeno-tonsillectomy in children is severe and sometimes last for days. Sufentanil is used by epidural route for postoperative analgesia in children. There are few reports about its use for postoperative analgesia by continuous intravenous infusion. Its complications include , hypoxia, sedation, pruritus ,nausea and/or vomiting. The investigators design this protocol to test efficacy of analgesia of three different rates of continuous intravenous sufentanil infusion for postoperative pain management following coblation tonsillectomy or adeno-tonsillectomy in children. The investigators also compare incidence rate of complications for three groups.

Study Type

INTERVENTIONAL

Allocation

RANDOMIZED

Purpose

TREATMENT

Masking

DOUBLE

Enrollment

Conditions

Sleep Breathing Disorders Tonsillitis Adenoid Hypertrophy

Interventions

Eligibility

Sex: ALLMin age: 5 YearsMax age: 8 Years

Medical Language ↔ Plain English

Inclusion Criteria: * American Society of Anesthesiologists grade I or II children aged 5-8 years undergoing coblation tonsillectomy or adeno-tonsillectomy as in-patient Exclusion Criteria: * Children with a history of adverse reaction to opioids, long-term use of opioid medications, and history of chronic pain. * Psychiatric illness, kidney failure, hypotension, atrioventricular block, myasthenia gravis etc.

Outcomes

Primary Outcomes

objective pain score

Time frame: up to 48 hours after operation

Secondary Outcomes

incidence rate of hypoxia

Time frame: 4h,8h,24h,48h after operation