Initial Safety Evaluation of FibroFix™ Meniscus

Inclusion Criteria: * The subject (or guardian, if appropriate) has signed and dated a specific informed consent form * The subject is over the age of 18 * The subject is able to comply with the protocol-defined preoperative procedures, the postoperative clinical and radiographic evaluations and the recommended rehabilitation regimen as determined by the investigator * The subject has a diagnosis of an MRI or arthroscopically confirmed irreparable medial meniscus defect * The meniscal defect should represent 25% or more of the meniscus and be amenable to repair * The peripheral meniscal rim must be present * The subject has a functionally intact anterior cruciate ligament * Haemoglobin \>9g/dL and platelet count \>100,000/mm3 prior to Day 1 * No contraindication to general anaesthetic * Female subjects of child-bearing potential: a negative urine pregnancy test Exclusion Criteria: * The subject has a functionally deficient anterior cruciate ligament * The subject has concomitant posterior cruciate ligament insufficiency of the involved knee or a concomitant injury that interferes with the subject's ability to comply with the recommended rehabilitation program * The subject has a diagnosis of untreatable Grade IV Outerbridge Scale degenerative cartilage disease in the involved knee joint * Patients demonstrating an active local or systemic infection * Any condition, which in the judgment of the Investigator would preclude adequate evaluation of the FibroFix™ Meniscus scaffold and clinical outcome. * The subject has a history of confirmed anaphylactoid reaction * The subject has received local administration of any type of corticosteroid or systemic administration of antineoplastic, immunostimulating, or immunosuppressive agents within 180 days prior to the scheduled surgery * The subject has evidence of osteonecrosis of the involved knee * The subject has a medical history that includes a confirmed diagnosis of rheumatoid or inflammatory arthritis, or relapsing polychondritis * If female and of child-bearing potential: evidence of a positive pregnancy test or a stated intention to become pregnant in the next 6-12 months