China Alair System Registry Study-CARE Study

Inclusion Criteria: 1. Patient is an adult aged 18 years or older with severe persistent asthma who remains symptomatic despite taking standard of care maintenance medications. 2. Patient is able to read, understand, and sign a written Informed Consent to participate in the Registry and able to comply with the study requirements. 3. Patient is able to undergo bronchoscopy in the opinion of the Investigator or per hospital guidelines and as described in the Alair System Directions for Use (DFU). Exclusion Criteria: 1. Patient has an implanted electrical stimulation device (e.g., a pacemaker, cardiac defibrillator, or deep nerve or deep brain stimulator). 2. Patient has any other medical condition that would make them inappropriate for study participation, in the Investigator's opinion.