This study is designed for establishment of non-alcoholic fatty liver disease patients cohort to development of markers to predict histologic progression of liver fibrosis.
* Acoustic radiation force impulse elastography and transient elastography * Liver tissue (frozen tissue, paraffin block) * Whole blood, Serum * Fat amount ratio CT (Visceral adipose tissue, Subcutaneous adipose tissue amount) * Body composition analyzer (InBody scale):Total fat/muscle mass and appendicular skeletal muscle mass * Pulmonary function test with post-bronchodilator response and DLCo * EKG, EchoCG, Heart CT (Coronary calcium score), and Pusle wave velocity (AI index, arterial stiffness) * Brain MRI or CT * Upper esophagogastroscopy and colonoscopy * Berlin score questionnaire and Polysomnography
Study Type
OBSERVATIONAL
Enrollment
1,000
Percutaneously liver biopsy will be performed for evaluate steatosis and fibrosis.
Acoustic radiation force impulse (ARFI) imaging will be performed for evaluate fibrosis of liver.
Supersonic shear wave elastography (SWE) will be performed for evaluate fibrosis of liver.
Seoul Metropolitan Government Seoul National University
Seoul, South Korea
RECRUITINGhistologic steatosis and fibrosis grade
We will evaluate fibrosis using laboratory examination, radiologic evaluation and liver tissue pathology.
Time frame: baseline
Development of markers for hepatic fibrosis progression
We will analysis and development fibrosis markers by obtained blood sample and liver tissue,
Time frame: baseline and every 6 months (up to 1year)
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Transient elastography will be performed for evaluate fibrosis of liver.