Study to Evaluate the Safety, Tolerability, Pharmacokinetics, and Pharmacodynamics of E2609 in Healthy Adult Male Japanese and White Subjects

Inclusion Criteria: The subject must meet all of the following criteria in order to be included in the study. Japanese Subjects Only: 1. Birth in Japan to Japanese parents and grandparents of Japanese descent 2. Have been living outside Japan for less than 5 years 3. Lifestyle, including diet, has not changed significantly since leaving Japan White Subjects Only: 4. A person having origins in any of the original peoples of Europe, the Middle East, or North Africa based on documented subject self-report All Subjects: 5. Healthy male, 30 to 60 years inclusive, at the time of informed consent 6. BMI of 18 to 32 kg/m2 inclusive at Screening 7. Subjects must have had a successful vasectomy (confirmed azoospermia) or they and their female partners must not be of childbearing potential or must be practicing highly effective contraception (i.e. condom plus spermicide, condom plus diaphragm with spermicide, intrauterine device starting for at least one menstrual cycle before starting study drug\[s\]) and throughout the study period and for 30 days after study drug discontinuation. No sperm donation is allowed during the study period and for 30 days after study drug discontinuation. Exclusion Criteria: Subjects who meet any of the following criteria will be excluded from this study: 1. Any history of seizures or epilepsy 2. Any medical condition which, in the opinion of the investigator has high risk of seizures 3. Any history of cerebrovascular disease 4. A history of prolonged QTc interval 5. Any other clinically significant ECG abnormalities 6. History of risk factors for torsade de pointes or the use of medications that prolonged the QT/QTc interval 7. Heart rate less than 50 or greater than 100 beats/min 8. History of ischemic heart disease 9. Persistent systolic blood pressure (BP) greater than 140 mmHg or less than 90 mmHg and diastolic BP greater than 90 mmHg or less than 60 mmHg 10. Left bundle branch block 11. Evidence of clinically significant disease 12. Any laboratory abnormalities considered clinically significant 13. Clinically significant illness which requires medical treatment 14. Any history of abdominal surgery that may affect study drugs 15. Hypersensitivity to the study drug 16. Known to be HIV positive 17. Active viral hepatitis 18. History of drug or alcohol dependency or abuse within approximately the last 2 years 19. Scheduled for surgery during the study 20. Engagement in strenuous exercise within 2 weeks before dosing (eg, marathon runners, weight lifters) 21. Currently enrolled in another clinical trial or used any investigational drug or device within 30 days before informed consent