Predictability of the Pulse Pressure Variation (PPV) During Spontaneous Ventilation on the Incidence of Hypotension During Induction of Anesthesia

N/AUnknownNCT02208570

Seoul National University Hospital172 enrolled

Overview

The purpose of this study is to find out the predictability of the pulse pressure variation during spontaneous ventilation on the incidence of hypotension during induction of anesthesia.

Study Type

INTERVENTIONAL

Allocation

RANDOMIZED

Purpose

PREVENTION

Masking

TRIPLE

Enrollment

172

Conditions

Hypotension

Interventions

PPV>14%OTHER

Patients whose preoperative pulse pressure variation during spontaneous ventilation exceed 14

Volume loadingDRUG

Hydroxyethyl starch solution 6ml/kg iv injection

PPV<14%OTHER

Patients whose preoperative pulse pressure variation during spontaneous ventilation does not exceed 14

Eligibility

Sex: ALLMin age: 20 YearsMax age: 80 Years

Medical Language ↔ Plain English

Inclusion Criteria: * Patients undergoing general anesthesia induction with intravenous anesthesia using propofol and remifentanil * Patients requiring invasive arterial blood pressure monitoring for the surgery Exclusion Criteria: * Refusal of consent * Patients with heart disease (symptomatic valvular heart disease, intracardiac shunt, pulmonary hypertension with pulmonary systolic arterial pressure exceeding 40mmHg) * FEV1 ≤ 50% predicted FEV1 * Patients with chronic renal failure * ASA class IV, V, VI * Systolic arterial blood pressure below 90mmHg before induction of anesthesia

Locations (1)

Seoul National University Hospital

Seoul, South Korea

RECRUITING

Outcomes

Primary Outcomes

Changes of heart rate and systolic arterial blood pressure from baseline values immediately before tracheal intubation

First, we measure the baseline heart rate and systolic arterial blood pressure and calculate the baseline heart rate and blood pressure. At 3 minutes after anesthesia agent injection we record the heart rate and blood pressure, and perform endotracheal intubation. Then we calculate the percentile change of blood pressure and heart rate from the baseline values.

Time frame: Three minutes after anesthesia agent injection

Secondary Outcomes

Changes of heart rate and systolic arterial blood pressure from baseline values, three minutes before intubation

We collect the patient's vital signs for 1 second interval during anesthesia induction. We collect the patient's heart rate and blood pressure values for three minutes before endotracheal intubation, and average the numbers. Then we compare the numbers from the baseline value and calculate the changes.

Time frame: Three minutes before endotracheal intubation

Changes of heart rate and systolic arterial blood pressure from baseline values, three minutes after intubation

We collect the patient's vital signs for 1 second interval during anesthesia induction. We collect the patient's heart rate and blood pressure values for three minutes after endotracheal intubation, and average the numbers. Then we compare the numbers from the baseline value and calculate the changes.

Time frame: Three minutes after endotracheal intubation

Central Contacts

Jae-Hyon Bahk

CONTACT

82-2-2072-2818 bahkjh@snu.ac.kr

Data from ClinicalTrials.gov

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