Effects of the Quadruple Immunosuppression on Peripheral Blood Lymphocytes and Development of Anti-HLA Antibodies in Kidney Transplant

Inclusion Criteria: * Men and women, ages 18 to 60 years inclusive * Percentage of Panel Reactive Antibodies at transplantation \> 20% * Estimated glomerular filtration rate using MDRD formula at inclusion \>29ml/min Exclusion Criteria: * Subjects with a history of cancer * Subjects with a previous non kidney transplantation * Subjects receiving any immunosuppression different of tacrolimus/prednisone/mycophenolate * Subjects with a urinary protein/creatinine ratio greater than 0.3 * Subjects with active HBV, HCV and HIV infection