Effectiveness and Safety of Method of Maxilla Alveolar Process Reconstruction Using Synthetic Tricalcium Phosphate and Autologous MMSCs

Inclusion Criteria: * Partially edentulous maxilla * Height of the bone tissue in the area of reconstruction 1 - 5 mm according to results of cone-beam computed tomography * Minimal height of the augmentation - 8 mm * Volume of bone tissue deficiency of the alveolar process of the maxilla 3 - 5 cm3 * Implant installation scheduled to be at least 6 months after sinus-lift operation * Patient is familiar with Participant information sheet * Patient signed informed consent form Non-inclusion Criteria: * Chronic and acute ear, nose and throat diseases, including maxillary sinusitis, foreign bodies in the maxillary sinus, odontogenic and not odontogenic maxillary sinus cyst * Medical history of surgery on maxillary sinuses during preceding 6 months prior to implantation of tissue engineered construction * Progressive somatic disease (clinically significant diseases of the cardiovascular, hematopoietic or endocrine system, systemic diseases, immunopathological states) * Patients with malignant tumors including postoperative period, patients receiving chemotherapy and/or radiotherapy * Any conditions limiting compliance (dementia, neuropsychiatric disease, drug and alcohol abuse etc.) * Significant weight loss (\> 10% of body weight in the previous year) of unknown etiology * Patient prescribed for any medications with proven effect on bone metabolism * Diabetes mellitus, disorders of thyroid and parathyroid glands * Clinically significant abnormalities in results of laboratory tests * Participation in other clinical trials (or administration of investigational drugs) during 3 months prior inclusion Exclusion Criteria: * Patient's refusal from the further participation in trial * Patient's refusal from compliance with the requirements of contraception during the participation in research * Plaque index (PI)\> 15% * Sulcus bleeding index (SBI) \> 10% * Chronic kidney disease IV - V stages (creatinine clearance \< 30 mL/min estimated by Cockroft-Gault formula) * Confirmed syphilis, HIV, hepatitis B or C infections Dropout Criteria: * Perforation of the Schneider's membrane more than 5 mm on the stage of the sinus-lift operation * Pregnancy