Effects of Low Dose Aspirin Pre-treatment on Platelet Activation Undergoing Off-pump Coronary Artery Bypass Surgery

N/ACompletedNCT02209909

Seoul National University Hospital48 enrolled

Overview

Platelet activation after off pump coronary artery bypass (OPCAB) surgery may affect thrombus formation. The purpose of this study is to assess the effects of preoperative continuation of aspirin on platelet activation after off pump coronary artery bypass surgery.

Patients undergoing OPCAB surgery will be randomized to continue preoperative aspirin or discontinue aspirin before surgery. Platelet activation can be evaluated by measuring platelet p-selectin using flowcytometry. In this study, we will compare platelet-activated markers and conventional coagulation tests.

Study Type

INTERVENTIONAL

Allocation

RANDOMIZED

Masking

DOUBLE

Enrollment

Conditions

Coronary Artery Disease

Interventions

aspirin continuationDRUG

Patients are randomized to continue aspirin before OPCAB surgery.

aspirin discontinuationDRUG

Patients are randomized to discontinue aspirin more than 4 days before OPCAB surgery.

Eligibility

Sex: ALLMin age: 20 YearsMax age: 80 Years

Medical Language ↔ Plain English

Inclusion Criteria: * age : 20-80 * elective OPCAB * informed consent Exclusion Criteria: * coagulation disorder * emergency operation, re-operation * co-existing valvular disease * less than 6 months after cerebral vascular accident * heparin induced thrombocytopenia * heparin resistance * menstrual phase * preoperative cardiopulmonary bypass, continuous veno-veno hemofiltration, intra-aortic balloon pump application * less than 12 months after myocardiac infarction * less than 10 days after unstable angina * less than 30 days after percutaneous coronary intervention * less than 6 wks after bare metal stent insertion * less than 12 months after drug eluting stent insertion

Locations (1)

Seoul National University Hospital

Seoul, South Korea

Outcomes

Primary Outcomes

change from baseline in platelet p-selectin at 48 hours after operation

Primary outcome is expression of platelet p-selectin measured by flowcytometry 48 hours after OPCAB surgery in both groups.

Time frame: after induction of anesthesia(baseline), at the time of end of operation, 24 hour after operation, 48hr after operation

Secondary Outcomes

change from baseline in conventional coagulation tests at the time of end of operation, 24 hour after operation, and 48hr after operation

prothrombin time (international normalized ratio), activated partial thromboplastin time, fibrinogen

Time frame: after induction of anesthesia(baseline), at the time of end of operation, 24 hour after operation, 48hr after operation

Data from ClinicalTrials.gov

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