Effect of Korean Red Ginseng on Central Blood Pressure in Patient With Essential Hypertension

Daegu Catholic University Medical Center58 enrolled

Overview

The purpose of this study is to determine Korean red ginseng (KRG)treatment could decrease central blood pressure in subjects with hypertension.

Participants with hypertension who were treated with antihypertensive agents were randomly assigned to an active (KRG 2 g/day) or a placebo treatment group in a double-blind cross over manner. Participants were not allowed to change their antihypertensive medications except safety issue. Brachial systolic BP (SBP), diastolic BP (DBP), Central SBP and DBP will measured at baseline,at 2 and 4 months. Efficacy and safety data will be monitored by Daegu Catholic University Medical Center Institutional Review Board and reported to the Korean Ginseng Society.

Study Type

INTERVENTIONAL

Allocation

RANDOMIZED

Purpose

SUPPORTIVE_CARE

Masking

DOUBLE

Enrollment

Conditions

Hypertension

Interventions

Korean Red Ginseng CapsulesDRUG

Korean Red Ginseng Capsules 2mg,daily, 8 week and than crossover to placebo capsules(2g), daily 8week

PlaceboDRUG

Korean Red Ginseng Capsules 2mg,daily, 8 week and than crossover to placebo capsules(2g), daily 8week

Eligibility

Sex: ALLMin age: 18 YearsMax age: 70 Years

Medical Language ↔ Plain English

Inclusion Criteria: * Essential hypertension * diastolic blood pressure 100 mmHg or less and systolic blood pressure 160 mmHg or less Exclusion Criteria: * Secondary hypertension * Serum creatinin above 1.5 mg/dL * aspartate aminotransferase(AST) and alanine aminotransferaseALT above two times upper normal limits * Uncontrolled diabetes (Hb A1c \< 9%) * Acute myocardial infarction or coronary artery disease intervention within six months * Moderate to severe congestive heart failure * HIV positive * Immunocompromized host * Allergy to Korean red ginseng * Pregnancy or plan to pregnancy * Alcohol or drug abuse * Attend to other clinical trial within 12 weeks

Locations (1)

Daegu Catholic University Medical Center

Daegu, South Korea

Outcomes

Primary Outcomes

central blood pressure change after treatment of Korea Red Ginseng

Time frame: baseline, 8 weeks and 16 weeks after treatment

Secondary Outcomes

brachial systolic and diastolic blood pressure

Time frame: baseline, 8 week, 16 week.

Augumentation index

Time frame: baseline, 8 week, 16 week.

ESR(erythrocyte sedmentation rate)

Time frame: baseline, 8 week, 16 week.

CRP(C-reactive protein)

Time frame: baseline, 8 week, 16 week.

Data from ClinicalTrials.gov

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