Tobramycin Inhalation Powder (TIP) in Cystic Fibrosis Patients Infected With Burkholderia Cepacia Complex

Inclusion Criteria: * Age 6 years or older * Diagnosis of CF based on the following: sweat chloride\>60 mEq/L or genotype with 2 identifiable mutations consistent with CF; and one or more clinical features consistent with CF. * Chronically infected with a Burkholderia cepacia complex species (\>50% of respiratory specimens positive in the 24 months prior to screening). * Able to produce sputum (expectorated or induced). * Able to reproducibly perform pulmonary function testing. * Written informed consent provided. Exclusion Criteria: * Post lung transplantation. * Pregnancy. * Acute exacerbation requiring IV or oral antibiotics within 14 days * Patients currently receiving inhaled tobramycin/TOBI * A septic or clinically unstable patient, as determined by the investigator.