The aim of the study 'Live - without diabetes' is to investigate the effects of increased physical activity on a daily basis with or without (high intense interval training) HIIT (short and intense: 3 minutes per week) during 12 weeks in risk individuals with pre-diabetes
A total of 125 individuals with pre-diabetes will be included and randomized into four different groups (N=25, each group): 1) Increased daily activity detected by the pedometer, 2) increased daily activity detected by the pedometer + HIIT, 3) HIIT, and 4) increased daily activity detected by the pedometer + group intervention 5) a control group (maintain unchanged activity and life-style during the duration of the study).
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
PREVENTION
Masking
NONE
Enrollment
59
Center for Diabetes Research, Gentofte Hospital
Hellerup, Denmark
Changes in insulin sensitivity
The primary endpoint is insulin sensitivity, and it will be assessed by changes in the area under the curve from baseline to end-of-study assessed by the Cederholm Index and Matsuda Index
Time frame: At baseline and after 12 weeks
Changes in oxygen peak oxygen uptake
Assessed from a physical fitness test (VO2peak)
Time frame: At baseline and after 12 weeks
Changes in glycaemic control
Measured as fasting plasma glucose, HbA1c
Time frame: At baseline and after 12 weeks
Changes in key proteins in glucose and fat metabolism (Skeletal muscle)
Expression/content of key proteins in skeletal muscle tissure (AU units)
Time frame: At baseline and after 12 weeks
Changes in body weight (kg)
Measured by Dual-energy X-ray Absorptiometry, DXA
Time frame: At baseline and after 12 weeks
Changes in key proteins in glucose and fat metabolism (Adipose fat tissure)
Expression/content of key proteins in adipose tissue (AU units)
Time frame: At baseline and after 12 weeks
Patient-reported outcome measure
Health related quality of life measured from Short Form 36 (SF36). Where scores are presented as norm-based scores (0-100) with higher scores indicating better perceived health status.
Time frame: At baseline and after 12 weeks
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