Verticality Perception - Multisensory Contribution

University of Zurich12 enrolled

Overview

The purpose of this study is to evaluate the relative contribution of head- and trunk-based sensory systems to internal estimates of direction of gravity in healthy human subjects. To implement this assessment experimentally, the investigators will use a motor-driven 3D-turntable and a thermoplastic mask to keep the head in a stable, either roll-tilted (±30°) or aligned with the trunk. The investigators will then obtain measurements of the subjective visual vertical in seven different whole-body roll positions (max. 90° roll-tilt). Analysis will be driven by a state-of-the art Bayesian integration model. The investigators hypothesize that different sensory input signals are combined in a statistically optimal fashion.

Study Type

INTERVENTIONAL

Allocation

Purpose

BASIC_SCIENCE

Masking

NONE

Enrollment

Conditions

Verticality Perception in Healthy Human Subjects Individual Contribution of Different Sensory Systems

Interventions

3D-video-head impulse testingOTHER

Evaluation of semicircular canal function. This intervention is part of the screening to determine suitability for this study

Vestibular-evoked myogenic potentials (VEMPs)OTHER

Evaluation of otolith function. This intervention is part of the screening to determine suitability for this study

Eligibility

Sex: ALLMin age: 18 YearsMax age: 60 YearsHealthy volunteers:

Medical Language ↔ Plain English

Inclusion Criteria: * ages 18-60 years * informed consent * absence of exclusion criteria Exclusion Criteria: * peripheral-vestibular deficit * disturbed consciousness * history of sensory deficits * visual field deficits * other neurological or systemic disorder which can cause dementia or cognitive dysfunction * intake of antidepressants, sedatives, or neuroleptics * pregnancy, unless excluded by a negative pregnancy test * known neck pain or status post neck trauma

Locations (1)

University Hospital Zurich, Dept. of Neurology

Zurich, Canton of Zurich, Switzerland

Outcomes

Primary Outcomes

Accuracy and precision of SVV adjustments in different head and trunk roll-tilt positions

Time frame: During the turntable measurement (90 minutes)

Secondary Outcomes

relative contribution of head- and trunk-based sensory systems based on Bayesian modelling

Time frame: while on the turntable (1.5 hours)

Data from ClinicalTrials.gov

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