Brain Mechanisms Underlying the Effect of the Motilin Receptor Agonist Erythromycin on Hunger in Normal Weight Subjects

Universitaire Ziekenhuizen KU Leuven14 enrolled

Overview

The purpose of this study is to investigate the role of erythromycin, a prokinetic agent, on hunger, and the brain mechanism lying behind it.

Study Type

INTERVENTIONAL

Allocation

RANDOMIZED

Purpose

BASIC_SCIENCE

Masking

SINGLE

Enrollment

Conditions

Healthy Volunteers

Interventions

ErythromycinDRUG

PlaceboDRUG

physiological saline

Eligibility

Sex: FEMALEMin age: 18 YearsMax age: 60 YearsHealthy volunteers:

Medical Language ↔ Plain English

Inclusion Criteria: * Female only. * Age \> 18 and \< 60. * Body Mass Index (BMI) of 19-25 kg/m2 (no weight change of more than 5 kg in the past three months). * Not known to have any chronic medical illness or illnesses affecting the gastrointestinal, cardiovascular, or nervous systems, chronic pain or psychiatric disorder. * If female not known to be pregnant. * Not known to have any past upper gastrointestinal surgery. Exclusion Criteria: * Alcohol consumption \> 7 drinks / week * Major depression and chronic health conditions except controlled hypertension

Outcomes

Primary Outcomes

Functional brain images

The functional brain images will be taken via functional magnetic resonance imaging (fMRI), and be analysed via a software called SPM.

Time frame: 40 min after intervention

Secondary Outcomes

hunger scores

The hunger scores will be taken every 10 minutes since the scan starts via a 10 cm visual analogue scale.

Time frame: every 10 minutes since the scan starts

gut hormones

Peripheral blood samples will be taken every 10 min since the scan starts until the endpoint of the study to measure gut hormones (motilin, ghrelin, CCK, PYY, GLP-1) by radioimmuno-assay.

Time frame: every 10 min since the scan starts

Data from ClinicalTrials.gov

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