Micro RNAs as a Marker of Aortic Aneurysm in Hereditary Aortopathy Syndromes

Inclusion Criteria: To be in the study, the participant must meet the following criteria 1. Diagnosis of hereditary aortopathy based upon: * Confirmation of a disease causing mutation in a known aortopathy disorder OR * Confirmation of disease based on published clinical criteria 2. Participants is male or female and greater than 30 days old 3. Participants are able to undergo standard of care cardiac monitoring including an echocardiogram 4. Willing and able to provide written informed consent by parent(s) or guardian(s) after the nature of the study has been explained and prior to any research related procedures 5. Signed HIPPA compliant research authorization Exclusion Criteria: Participant will be excluded from the study for any of the following criteria 1. Diagnosis of a hereditary aortopathy can not be confirmed 2. Existence of an additional comorbid condition- including a co-existing genetic syndrome, heart failure, renal disease, rheumatologic disease, history of malignancy, thyroid disease, recent stroke, other life-limiting illness not related to cardiovascular disease. 3. Extreme prematurity, \<28 weeks gestational age