Treatment of Port Wine Stains Using Pulsed Dye Laser, Erbium Yag Laser and Topical Sirolimus

Inclusion Criteria: * Subject has provided informed consent; * Subject is ≥ 18 years of age at time of screening; * Subject has an extra-facial homogenous Port Wine Stain (PWS); * The PWS is large enough in size to fit one of the templates * Subject has not received any laser treatment of the PWS in the last 3 months (in the treatment area); * The PWS has a minimal erythema grading score of 3 (on a 4 point scale) in the opinion of the investigator; * Screening blood safety values are within normal parameters or regarded as not clinically significant in the opinion of the investigator. Exclusion Criteria: * PWS with a nodular/hypertrophic component in the treatment area; * PWS on cosmetically unacceptable locations in the opinion of the investigator; * For women: pregnant or breast feeding during the treatment period; * Women of child-bearing potential, unless they are using adequate contraceptive measures * Subject is known to have immune deficiency, or is immune compromised * Known allergy to sirolimus or other constituents of the study medication; * Incapacitated subjects; * Any medical or psychiatric condition which, in the investigator's opinion, would preclude the participant from adhering to the protocol or completing the study per protocol.