This randomised, multi-center, controlled trial is designed to assess the efficacy and safety of icotinib with concurrent radiotherapy versus chemotherapy with concurrent radiotherapy in non-small cell lung cancer
This randomised, multi-center, controlled trial is designed to assess the efficacy and safety of icotinib with concurrent radiotherapy versus etoposide/cisplatin with concurrent radiotherapy in stage III non-small cell lung cancer with EGFR 19/21 Mutation, the primary endpoint is progression-free survival
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
TREATMENT
Masking
NONE
Enrollment
120
Icotinib: 125 mg is administered orally three times per day.
Etoposide 50mg/m2, ivgtt, d1-d5; cisplatin 50mg/m2, ivgtt, d1 and d8, every 28 days for a cycle, a total of 2 cycles
Chinese Academy of Medical Sciences Cancer Hospital
Progression-free survival
Time frame: 24 months
Overall survival
Time frame: 36 months
Objective response rate
Time frame: 8 weeks
Adverse events
Time frame: 54 months
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Beijing, Beijing Municipality, China
People's Liberation Army 307 Hospital
Beijing, Beijing Municipality, China
Peking University Third Hospital
Beijing, Beijing Municipality, China
Beijing Union Medical College Hospital
Beijing, Beijing Municipality, China
Dongguan City People's Hospital
Dongguan, Guangdong, China
Sun Yat-sen Cancer Hospital
Guangzhou, Guangdong, China
Nanfang Hospital
Guangzhou, Guangdong, China
Guangxi Zhuang Autonomous Region People's Hospital
Nanning, Guangxi, China
Cancer Hospital of Harbin Medical University
Harbin, Heilongjiang, China
First Affiliated Hospital of Zhengzhou University
Zhengzhou, Henan, China
...and 16 more locations