Human milk is the best source of enteral nutrition for the preterm infant. However during the infants first hours and days of life breastmilk from the own mother is usually not available. Until May 2012 the practice in the Neonatal Division of the Department of Pediatrics /Medical University Vienna was to start with formula feedings within the first 6 hours of life of a premature infant and switch over to breastmilk as soon it was available. In June 2012 the investigators changed this feeding regimen and started to use single donor milk of mothers of preterm infants for the first hours and days of the preterm infants life. In a prospective observational study the investigators evaluated the impact of single donor milk from preterm infants on time to full enteral feedings, gastrointestinal tolerance and NEC incidence in preterm infants with a birthweight below 1500 grams and a gestational below 32 weeks. Data will be compared with a historical control group starting with preterm formula as source of enteral nutrition. The investigators hypothesize that starting enteral nutrition with single donor milk of mothers from preterm infants with shorten time to full enteral feedings.
Study Type
OBSERVATIONAL
Enrollment
300
Infants received preterm formula during their first days of life until breastmilk from their own mother was available
Infants received preterm single donor milk during their first days of life until breastmilk from their own mother was available
Medical University of Vienna
Vienna, Austria
Time to full enteral feeding
Full enteral feedings are defined as an enteral inane of 135-145ml/kg/d
Time frame: birth up to 40 weeks of gestation
necrotizing enterocolitis
Necrotising enterocolitis (NEC) was defined according to the stages by Bell as proven NEC grade 2a.
Time frame: birth to 40 weeks of gestation
Gastric residuals
Gastric residuals are a parameter for gastrointestinal tolerance and are determined every three hours before the next meal is given and are aspirated via a gastric tube Gastric residuals are measured in ml/kg per meal. Furthermore the color is documented (milky, clear, mucous, bile stained, bloody)
Time frame: birth to 7th day of life
Frequency of stool
Number of stools per day
Time frame: birth until 14th day of life
culture positive sepsis
Time frame: birth to 40th week of gestation
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