The investigators will test the central hypothesis that DFO treatment after SAH may improve cerebrovascular regulation, mitigate ischemic neural injury, and serve as an effective neuroprotectant against delayed ischemic injury after SAH.
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
TREATMENT
Masking
QUADRUPLE
Enrollment
2
DFO (20mg/kg/hr) in normal saline for 4 hours for 5 consecutive days
normal saline IV for 4 hours for 5 consecutive days
Brigham and Women's Hospital
Boston, Massachusetts, United States
delayed cerebral ischemia (DCI)
DCI will be defined radiographically as any cerebral infarct on the latest CT scan that was seen within 6 weeks after SAH or before discharge or death, that was not present on admission scan or on the CT scan done within 24 to 48 hours after any aneurysmal treatment procedures. All head CT scans will be reviewed for DCI ascertainment by neuroradiologists blinded to the clinical and TCD data using the standardized protocol.
Time frame: 6 weeks post hemorrhage
Clinical outcome at discharge
Clinical outcome at discharge will be assessed using modified Rankin Scale (mRS) as a global functional status. The modified Rankin scale evaluates global disability and handicap; scores range from 0 (no symptoms or disability) to 6 (death). Good mRS will be defined as score of ≤ 2.
Time frame: patient's discharge date, which averages 3-4 weeks post hemorrhage
This platform is for informational purposes only and does not constitute medical advice. Always consult a qualified healthcare professional.