Phase 2 Study of KHK7580

Inclusion Criteria: * Subjects who have voluntarily consented to participate in this study * Subjects with stable chronic renal disease receiving hemodialysis 3 times weekly for at least 12 weeks before screening * Subjects with an intact Parathyroid hormone of \>= 240 pg/mL at screening Exclusion Criteria: * Subjects with primary hyperparathyroidism * Subjects who have received cinacalcet hydrochloride within 2 weeks before screening * Subjects whose dose or dosing regimen of an active vitamin D drug or its derivative, phosphate binders, or calcium preparation has been changed or started within 2 weeks before screening. * Subjects who have underwent parathyroidectomy and/or parathyroid intervention within 24 weeks before screening. * Subjects with uncontrolled hypertension and/or diabetes * Subjects with severe heart disease. * Subjects with severe hepatic dysfunction. * Subjects who have received any other investigational drug within 12 weeks before screening * Other subjects unfit for participation in this study in the judgment of the investigator or sub investigator.