In a previous protocol, we highlighted an excessive daytime sleepiness at the Maintenance of Wakefulness Tests (MWT) in 36% of adult Attention Deficit Disorder with or without Hyperactivity (ADHD) patients. In 40% of cases this sleepiness was associated with a sleep disorder objectified by polysomnography (PSG): apnea hypopnea syndrome (AHI) ≥ 10/h and / or Periodicals Movements of Lower Limb (PLMI) ≥ 15/h. However, among patients with no sleep disorder PSG, we can question the central origin of the Excessive Daytime Sleepiness. Thus, we wish to determine potential changes in the regulation of sleep / wake cycle through a protocol of extended wake. The principal objective is to compare the objective sleepiness in sleepy patients with ADHD and healthy subjects during a protocol of extended wake. It's an observational study of interventional type realized in patient with ADHD syndrome deprived of psychostimulant treatment (for 72 hours) and healthy subject, investigating the implication of the homeostatic and circadian systems in the preservation of awakening.
Study Type
INTERVENTIONAL
Allocation
NON_RANDOMIZED
Purpose
BASIC_SCIENCE
Masking
NONE
Enrollment
19
The tests are : Go/NoGo paradigm, Continuous Performance Test (CPT) II , Wisconsin Card Sorting Test (WCST), virtual CPT, Classic and virtual Stroop, PSG, MWT These tests will be repeated during 32h each 4h (T0h, T4h, T8h, T12h, T16h, T20h, T24h, T28h et T32h).
CHU de Bordeaux
Bordeaux, France
Comparison of objective sleepiness
Comparison of objective sleepiness in sleepy patients with ADHD and healthy subjects during a protocol of extended wake.
Time frame: at inclusion (day 0)
Theta-alpha band of EEG sleep
Time constant and asymptotic value of the spectral power of the theta-alpha band of EEG sleep
Time frame: At inclusion (Day 0)
Amplitude and phase of internal temperature
Time frame: At inclusion (day 0)
Score of Karolinska Sleepiness Scale (subjective measure of sleepiness)
Time frame: At inclusion (day 0)
Results of the neuropsychological tests
* Go/NoGO paradigm * Continuous Performance Test and virtual Continuous Performance Test * Stroop test and virtual stroop test * Wisconsin Card Sorting Test
Time frame: At inclusion (day 0)
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