The purpose of this study is to determine the effects of an oral fructose challenge on liver adenosine triphosphate (ATP) reserves using 31P magnetic resonance spectroscopy (MRS) as a potential measure measure of liver health.
This study uses 31P spectra acquired from the liver in healthy subjects following a fructose drink to monitor ATP levels. This is also related to baseline BMI, liver glycogen and liver lipid levels
Study Type
INTERVENTIONAL
Allocation
NA
Purpose
BASIC_SCIENCE
Masking
NONE
Enrollment
10
Oral Fructose Challenge (75 g fructose in 500 ml water) following overnight fast
University of Nottingham
Nottingham, Nottinghamshire, United Kingdom
Hepatic ATP reserves following an oral fructose challenge
Monitor hepatic ATP levels following an oral fructose challenge using 31P magnetic resonance spectroscopy
Time frame: 2 hours post prandial
Correlate hepatic ATP depletion / recovery with BMI, liver lipids and liver glycogen
Measure baseline liver lipid and glycogen using magnetic resonance spectroscopy and correlate BMI, lipid and glycogen levels with rate of ATP depletion and recovery following an oral fructose challenge
Time frame: 2 hours post prandial
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