A Study of the Abuse Liability Potential of Samidorphan in Healthy, Non-Dependent, Recreational Opioid Users

Inclusion Criteria: * Be in good general physical health * Body mass index of 18-34 kg/m2, inclusive with minimum weight of 50 kg * Recreational opioid use experience for non-therapeutic purposes (at \>/= 10 times in lifetime and \>/= 1 in previous 3 months * Agree to use an approved method of birth control for the duration of the study * Additional criteria may apply Exclusion Criteria: * Currently pregnant or breastfeeding * History of or current infection with hepatitis B virus, hepatitis C virus or HIV * Current or history of any clinically significant medical or psychiatric condition * Current or history of in the last 2 years of dependence on alcohol or any illicit drugs * Have used any prescription or over-the-counter medication, including natural health products (with the exception of prescription birth control or hormonal replacements, acetaminophen, ibuprofen, or multivitamins) within 14 days * Have a history of intolerance or hypersensitivity to opioid antagonists, opioid agonists or related drugs (eg, naltrexone, naloxone, oxycodone, morphine) * Additional criteria may apply