Performance Evaluation of the Micromedic BRONJ Risk Assessment in Vitro Diagnostic Assay

Inclusion Criteria: Inclusion Criteria Study Group (all of the following): 1. Subject is ≥18 years old 2. Subject is or was a Multiple Myeloma and/or other cancer patient who is or has been IV treated with the BP zoledronic acid and/or pamidronate disodium; Or; Subject is or was a Multiple Myeloma and/or other cancer patient who is or has been IV treated with the BP zoledronic acid and/or pamidronate disodium and was also treated by oral BP such as sodium alendronate, and in the opinion of the PI, IV treatment was significant enough to be considered as the cause for BRONJ 3. Subject has been diagnosed with BRONJ at stages 1 or 2 or 3 according to AAOMS (American Association of Oral and Maxillofacial Surgeons) 4. Subject has signed the informed consent or consent can be waived Inclusion Criteria Control Group (all of the following): 1. Subject is ≥18 years old 2. Subject is or was a Multiple Myeloma and/or other cancer patient who is, or has been IV treated with the BP zoledronic acid and/or pamidronate disodium for at least two (2) years (continuously or cumulatively) 3. Subject has not developed any signs or symptoms of BRONJ 4. Subject has signed the informed consent or consent can be waived Exclusion Criteria: 1. Subject has been treated with irradiation to the jaws or head and neck at levels exceeding 35 Gy 2. Pregnant or lactating women 3. Subject has been treated with either bevacizumab or sunitimib 4. Subject has been treated with Allogeneic hematopoietic stem cell transplantation (HSCT)