A Prospective Colorectal Liver Metastasis Database With an Integrated Quality Assurance Program

Inclusion Criteria: * With histologically proven colorectal adenocarcinoma with liver metastasis. * With unresectable, borderline or initially unresectable liver metastasis from a colorectal cancer assessed by a clinician or by a multi-disciplinary tumor board (MDT). * Unresectable is defined as no possibility of completely resecting all tumor due to size, location or number of deposits. * Borderline is defined as potentially operable but technically or biologically more challenging to resect as evaluated by the MDT. * Initially unresectable is defined as metastasis that have been down-sized after conversion chemotherapy and evaluated by the MDT to be resectable * discussed by a multidisciplinary team before surgery. * Participants of the MDT must include at least one liver surgeon, one radiologist and one oncologist. They will determine the resectability of the CRLM according to local practice. * With a possibility of a surgical procedure (resection with or without portal vein embolization, intraoperative local ablative technique or a combined approach) assessed during the MDT. * Age ≥ 18 years. * Before patient registration, written informed consent must be given according to ICH/GCP, and national/local regulations. Exclusion Criteria: * Any psychological, familial, or sociological condition potentially hampering understanding of the research project. * Any other malignancy other than in situ carcinoma of the cervix or non-melanoma skin cancer (unless there has been a disease-free interval of at least 5 years)