Restoring Glutathione Synthesis With Tecfidera: An in Vivo H-MRS Single-Arm Study at 7T in Patients With RR MS

Inclusion Criteria: * Male or female adult patients * 18-60 years of age * Diagnosis of multiple sclerosis, in accordance with the revised McDonald criteria (2010) * Patients naive to MS therapy or patients switching from an FDA-approved MS therapy, including IFN-B formulations, Cop-1, Teriflunomide, and Fingolimod to BG-12 * Expanded Disability Status Scale (EDSS) score 0 to 5.5 inclusive Exclusion Criteria: * Primary progressive multiple sclerosis patients * Patients with previous exposure or known allergies to fumarates * MS patients switching from natalizumab, cyclophosphamide, or mitoxantrone to BG-12 * Contraindications for MRI/MRS * Known presence of other neurological disorders that may mimic multiple sclerosis * Pregnancy or lactation * Requirement for chronic treatment with systemic corticosteroids or immunosuppressants during the course of the study * History of or currently active primary or secondary immunodeficiency * Active infection, or history of or known presence of recurrent or chronic infection (e.g. hepatitis B or C, HIV, syphilis, tuberculosis\_ * History of progressive multifocal leukoencephalopathy * Contraindications to or intolerance of oral or intravenous (IV) corticosteroids