Immunologically evaluation of myeloperoxidase level as indicator for inflammatory reactions on modified surface abutments compared to machined surface abutments.
One study abutment per patient will be placed. After healing for 6 to 7 weeks, patients will be asked to stop oral hygiene at the study site for 2 weeks. Sulcus fluid and plaque samples will be taken at the abutment site at several visits before and during abdication of oral hygiene. The study finishes with biopsy visit. Afterwards a regular abutment will be placed and the patients will be treated according to the standard protocol of the clinic to obtain their final restoration
Study Type
INTERVENTIONAL
Allocation
NA
Masking
NONE
Enhanced Soft Tissue Attachment surface on Roxolid or machined surface on Roxolid abutment placement.
Universität Bern
Bern, Canton of Bern, Switzerland
Evaluation of Myeloperoxidase level as indicator for inflammatory reactions on modified surface abutments compared to machined surface abutments.
A biopsy will be taken at study day 70. The study abutment will be removed together with a small slice of the surrounding soft tissue to histologically evaluation.
Time frame: Inflammation assessment and biopsy at study day 70.
Evaluation of myeloperoxidase level of modified surface abutments compared to machined surface abutment at visit 2, 3, 4, and 6.
A immunology sample will be taken 2-3 weeks after abutment placement, followed on week 6-7, week 8, week 9, and at week 20-24.
Time frame: 20-24 weeks
evaluation of inflammatory parameters of modified surface abutment compared to machined surface abutments
A immunology sample will be taken 2-3 weeks after abutment placement, followed on week 6-7, week 8, week 9, and at week 20-24.
Time frame: 20-24 weeks
Evaluation of clinical inflammatory parameters of modified surface abutments compared to machined surface abutments based on modified Mombelli plaque index and modified Lobene gingival index.
A immunology sample will be taken 2-3 weeks after abutment placement, followed on week 6-7, week 8, week 9, and at week 20-24.
Time frame: 20-24 weeks
Evaluation of subgingival plaque extension of modified surface abutments compared to machined surface abutments
Patients will be asked to suspend oral hygiene in the area of the abutment. after 42-49 days after abutment placement for 14 days. At study week 8 a histological sample will be taken
Time frame: 9 weeks after abutment placement
Evaluation of soft tissue around the abutment of modified surface abutment compared to machined surface abutments
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8 weeks after abutment placement patients have been asked for 14 days of abdication of oral hygiene. A histological sample will be taken then.
Time frame: At 8 weeks after abutment placement
Evaluation of bacterial community at the abutment site
At study day 42-49, day 49-56, day 56-63, and day 77-105 a microbiological sample will be taken
Time frame: 28 days