Comparison of Premixed Insulin With Basal-plus Insulin in Type 2 Diabetes Patients

Inclusion Criteria: * Men and women with type 2 diabetes.(World Health Organization classification) \> 20 years of age. * Patients who have received stable doses of any OADs for at least 12 weeks prior to the screening visit. * treatment with basal insulin plus OADs \>3 months with suboptimal glycemic control (HbA1c \>7%) * FBG \<130 mg/dl or FBG ≥130 mg/dl, but daily insulin dose \>0.7U/kg or had history of nocturnal hypoglycemia * Patients who are willing and able to cooperate with study and give signed informed consent. Exclusion Criteria: * Patients with type 1 diabetes. * History of severe hypoglycemia or hypoglycemia unawareness within prior 6 months. * Patients who had received any investigational insulin for more than 3 months or who have received investigational insulin treatment within 4 weeks prior to screening visit. * Patients hypersensitive with insulin analog or its excipients. * Patients who are currently pregnant/lactating, or who are preparing for pregnancy or lactation. * Renal dialysis patients, patients with severe liver disease or congestive heart failure * BMI \>40kg/m2 * Excessive insulin resistance (total daily insulin dose\>2.0unit/kg)