Dynamic Assessment of Right Ventricular Function With Inhaled Nitric Oxide During Cardiac MRI

Early Phase 1CompletedNCT02220023

Vanderbilt University17 enrolled

Overview

The purpose of the study is to measure RV ejection fraction (RVEF), pulmonary flow, and pulmonary perfusion before and after exposure to inhaled nitric oxide in patients with pulmonary arterial hypertension (PAH) who are known to be vasodilator-responsive based on invasive catheterization as well as healthy subjects. Measurements will also be made after high flow oxygen alone to test the relative vasodilatory effect of oxygen and NO. The investigators hypothesize is that inhaled nitric oxide during cardiac MRI can be used to measure dynamic changes in RV-pulmonary vascular function in patients with vasodilator-responsive PAH.

Study Type

INTERVENTIONAL

Allocation

Purpose

DIAGNOSTIC

Masking

NONE

Enrollment

Conditions

Pulmonary Vascular Disorder

Interventions

Eligibility

Sex: ALLMin age: 18 Years

Medical Language ↔ Plain English

Inclusion Criteria: * Patients age 18 or older of the Vanderbilt Center for Pulmonary Vascular Disease. Vasodilator-responsive patients will be identified based on prior response to inhaled nitric oxide during invasive right heart catheterization * Healthy subjects age 18 or older not known to have cardiopulmonary disease Exclusion Criteria: * Standard conventional contraindications for cardiac magnetic resonance (CMR) imaging * Allergy or contraindication to Magnevist (gadopentetate dimeglumine) contrast * Concurrent intravenous epoprostenol infusion in whom performance of CMR is cumbersome * Pregnant women

Outcomes

Primary Outcomes

Right ventricular ejection fraction (RVEF) before and after inhaled nitric oxide exposure

Time frame: At time of procedure

Secondary Outcomes

Pulmonary flow

Time frame: Baseline, after 4 minutes high flow oxygen, after 4 minutes high flow oxygen plus nitric oxide

Pulmonary perfusion

Time frame: Baseline, after 4 minutes of high flow oxygen, after 4 minutes of high flow oxygen plus nitric oxide

Estimates of pulmonary vascular resistance

Time frame: At Baseline, after 4 minutes of high flow oxygen, after 4 minutes of high flow oxygen plus nitric oxide

Pulmonary transit time

Time frame: At baseline, after 4 minutes high flow oxygen, after 4 minutes high flow oxygen plus nitric oxide

Pulmonary artery compliance