This is a double-blind randomized clinical trial which will start at June 2014 and end on June 2015 in Isfahan city. Serum creatinine level is considered as a key variable and the sample size calculated 80 persons (40 persons for control group and 40 persons for patient group). Patients aged more than 18 years old with diabetic nephropathy having Fasting Blood Sugar more than 126 mg/dL and proteinuria 30-300 mg/dL (microalbuminuria) and Glomerular Filtration Rate more than 90 mL/min will be chosen. Patient group will receive magnesium supplement (250 milligram) and the other group will receive placebo which is similar to the magnesium tablets in color, odor and appearance both for 12 weeks. All subjects will complete 4 physical activity and 4 dietary records. Outcome measurements including metabolic, renal and inflammatory profiles will be measured at the beginning and end of the study as well as anthropometric measurements.
This is a double-blind randomized clinical trial which will start at June 2014 and end on June 2015 in Isfahan city. Serum creatinine level is considered as a key variable and the sample size calculated 80 persons (40 persons for control group and 40 persons for patient group).
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
TREATMENT
Masking
DOUBLE
Enrollment
80
Patients aged more than 18 years old with diabetic nephropathy having Fasting Blood Sugar more than 126 mg/dL and proteinuria 30-300 mg/dL (microalbuminuria) and Glomerular Filtration Rate more than 90 mL/min will be chosen. Patient group will receive magnesium supplement (250 milligram) and the other group will receive placebo which is similar to the magnesium tablets in color, odor and appearance both for 12 weeks. All subjects will complete 4 physical activity and 4 dietary records. Outcome measurements including metabolic, renal and inflammatory profiles will be measured at the beginning and end of the study as well as anthropometric measurements.
Isfahan University of Medical Sciences
Isfahan, Isfahan, Iran
Serum creatinine
Time frame: 12 weeks
Blood Urine Nitrogen
Time frame: 12 weeks
Glomerular Filtration Rate
Time frame: 12 weeks
Proteinuria
Time frame: 12 weeks
Fasting Blood Sugar
Time frame: 12 weeks
Hemoglobin A1c
Time frame: 12 weeks
Serum insulin level
Time frame: 12 weeks
High Density Lipoprotein
Time frame: 12 weeks
Low Density Lipoprotein
Time frame: 12 weeks
Very Low Density Lipoprotein
Time frame: 12 weeks
Triglyceride
Time frame: 12 weeks
Total Cholesterol
Time frame: 12 weeks
high sensitive C-Reactive Protein
Time frame: 12 week
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