Hemabate is often used for gynecological patients. Hemabate is associated with many side effects, including a burning sensation in the stomach, nausea, vomiting, diarrhea etc. It is reported that dexmedetomidine reduce gastrointestinal reaction during perioperative period. We design this clinical trial to find if dexmedetomidine can prevent the side effects of hemabate in Cesarean Section patients.
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
PREVENTION
Masking
TRIPLE
Enrollment
120
received 20 ml intravenous physiological saline The infusion were completed in 30 minutes.
received 0.5μgkg-1 intravenous dexmedetomidine (Jiang Su Heng Rui Medicine Co. Ltd, Jiangsu Province, China) diluted to 20ml with physiological saline The infusion were completed in 30 minutes.
received 1μgkg-1 intravenous dexmedetomidine (Jiang Su Heng Rui Medicine Co. Ltd, Jiangsu Province, China) diluted to 20ml with physiological saline. The infusion was completed in 30 minutes
SpO2 Change
Time frame: participants will be followed for the duration of surgery, an expected average of 2 hours
systolic blood pressure and diastolic blood pressure change
Time frame: participants will be followed for the duration of surgery, an expected average of 2 hours
Heart rate change
Time frame: participants will be followed for the duration of surgery, an expected average of 2 hours
nausea
Time frame: 24 h postoperatively
vomiting
Time frame: 24h postoperatively
fever
Time frame: 24h postoperatively
diarrhea
Time frame: 24h postoperatively
headache
Time frame: 24h postoperatively
elevated blood pressure
Time frame: 24h postoperatively
chest congestion
Time frame: 24h postoperatively
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