Edoxaban for TIA and Acute Minor Stroke

Inclusion Criteria: * Adult subjects (male or female ≥18 years old) * Acute nondisabling ischemic stroke (NIHSS ≤3 at the time of randomization) that can be treated with study drug within 24 hours of symptoms onset. Symptom onset is defined by the "last see normal" principle * TIA (neurologic deficit attributed to focal brain ischemia, with resolution of the deficit within 24 hours of symptom onset), that can be treated with investigational medication within 24 hours of symptoms onset. Symptom onset is defined by the "last see normal" principle * Informed consent signed Exclusion Criteria: * Diagnosis of hemorrhage or other pathology, such as vascular malformation, tumor, abscess or other major nonischemic brain disease, on baseline head CT or MRI scan * mRS score \>2 at randomization (premorbid historical assessment) * NIHSS ≥4 at randomization * Clear indication for anticoagulation (atrial fibrillation, mechanical cardiac valves, deep venous thrombosis, pulmonary embolism or known hypercoagulable state) * Contraindication to investigational medications * Thrombolysis for ischemic stroke within preceding 7 days * History of intracranial hemorrhage * Current treatment (last dose given within 10 days before randomization) with heparin therapy or oral anticoagulation * Gastrointestinal bleed or major surgery within 3 months * Planned or likely revascularization (any angioplasty or vascular surgery) within the next 3 months * TIA or minor stroke induced by angiography or surgery * Severe noncardiovascular comorbidity with life expectancy \<3 months * Women of childbearing age not practicing reliable contraception who do not have a documented negative pregnancy test result * Severe renal failure, defined as Glomerular Filtration Rate (GFR) \<30 ml/min -Severe hepatic insufficiency (Child-Pugh score B to C)