Study to Evaluate the Preliminary Safety, Efficacy, PK and PD of Bryostatin 1 in Patients With Alzheimer's Disease

Inclusion Criteria: * Male or female, age 50 - 85 yrs. Females are non-childbearing potential * Patient must have a cognitive deficit present for at least 1 year and meet diagnostic criteria for probable Alzheimer's Disease Dementia by NIA-AA criteria or prodromal Alzheimer's Disease * Mini Mental State Exam score of 16-26 * Ability to walk, at least with an assistive device * Vision and hearing sufficient to comply with testing * Normal cognitive and social functioning prior to onset of dementia, with evidence of progressive symptoms from patient or informant * Consistent caregiver to accompany patient to visits * Sufficient basic education to be able to complete the cognitive assessments * Living outside an institution Exclusion Criteria: * Dementia due to any condition other than AD, including vascular dementia * Significant neuroimaging abnormalities, previously known or discovered on screening MRI scan, * Evidence of clinically significant unstable cardiovascular, renal, hepatic, gastrointestinal, neurological, or metabolic disease within the past 6 months * Use of any drug within 14 days prior to randomization unless the dose of the drug and the condition being treated have been stable for at least 30 days and are expected to remain stable during the study * Use of tobacco products or nicotine-containing products within 3 months before Day 1 * Use of high dose vitamin E, or valproic acid * Any medical or psychiatric condition that may require medication or surgical treatment during the study * Life expectancy less than 6 months * Use of an investigational drug within 2 months prior to the screening visit * Clinically significant neurological disease other than AD * Major depression, alcohol or drug dependence or suicidality * Psychotic episodes requiring hospitalization or antipsychotic therapy for more than 2 weeks within the past 10 years, not linked to AD * Agitation sufficient to preclude participation in this trial * Epilepsy or anti-epileptic drug therapy * Abnormal laboratory tests that might point to another etiology for dementia; * Acute or poorly controlled medical illness * Likelihood, according to clinical judgment, of being transferred to a nursing home within 6 months